منابع مشابه
Anticoagulant treatment with rivaroxaban in severe protein S deficiency.
We report a case of a 6-year-old girl with severe protein S deficiency due to a homozygous mutation and recurrent episodes of skin necrosis. She developed purpura fulminans at birth and a catheter-related venous thrombosis complicated by massive pulmonary embolism at the sixth day of life. Long-term oral anticoagulant therapy with a vitamin K-antagonist was started with a therapeutic range of t...
متن کاملAnticoagulant Treatment With Rivaroxaban in Severe Protein S Deficiency abstract
We report a case of a 6-year-old girl with severe protein S deficiency due to a homozygous mutation and recurrent episodes of skin necrosis. She developed purpura fulminans at birth and a catheter-related venous thrombosis complicated by massive pulmonary embolism at the sixth day of life. Long-term oral anticoagulant therapy with a vitamin K-antagonist was started with a therapeutic range of t...
متن کاملProtein S: an anticoagulant in its own right.
Editorial on Heeb et al. Thromb Haemost 2012; 107: 690-698. Since the isolation of protein S in 1979, initial studies demonstrated that protein S acted as a natural anticoagulant by promoting the serine protease activity of activated protein C (APC) on its substrates, the coagulation factors Va and VIIIa. This interaction required binding to phospholipid membranes through the vitamin K-dependen...
متن کاملSpecies-specific anticoagulant and mitogenic activities of murine protein S.
BACKGROUND The protein C pathway down-regulates thrombin generation and promotes cytoprotection during inflammation and stress. In preclinical studies using models of murine injury (e.g., sepsis and ischemic stroke), murine protein S may be required because of restrictive species specificity. DESIGN AND METHODS We prepared and characterized recombinant murine protein S using novel coagulation...
متن کاملParticipation of endothelial cells in the protein C-protein S anticoagulant pathway: the synthesis and release of protein S
The protein C-protein S anticoagulant pathway is closely linked to the endothelium. In this paper the synthesis and release of the vitamin K-dependent coagulation factor protein S is demonstrated. Western blotting, after SDS PAGE of Triton X-100 extracts of bovine aortic endothelial cells grown in serum-free medium, demonstrated the presence of protein S. A single major band was observed at Mr ...
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ژورنال
عنوان ژورنال: Biomedical Research and Clinical Practice
سال: 2017
ISSN: 2397-9631
DOI: 10.15761/brcp.1000151